original article

Vol. 8 No. 1

MINIMAL HEPATIC ENCEPHALOPATHY AMONGST CHRONIC LIVER DISEASE PATIENTS IN A HOSPITAL: NEED FOR COGNITIVE EVALUATION?

June 2016

— Nwabuaku OJ, Onyekwere CA and Ogun SA

Abstract

Background: Minimal Hepatic Encephalopathy (MHE) reflects the earliest stage of HE, its identification is important to retard its progression.

Objectives: To determine the prevalence of MHE amongst patients with chronic liver disease (CLD) in a tertiary hospital in Lagos State.

Materials and Methods: Following ethical approval, a record form was used to evaluate the clinical and laboratory features of 65 consecutive patients with CLD, and 65 controls. A MMSE and two neuropsychometric tests: NCT-A and NCT-B were administered to all subjects. EEG was done on 32 patients and venous ammonia assays carried out on all subjects. MHE was present if there are two abnormal neuropsychometric tests, or one abnormal neuropsychometric test with an abnormal EEG. A p value of

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